Research


Research interests

Research Team: please visit our team site: BioMedical Informatics and Processes 

    Biomedical systems introduce many modeling challenges, including:

    The modeling methods that I am using are draw from the following areas:

Current projects

Previous projects

Modeling and executing clinical guidelines – developing modeling methodologies and tools for specifying narrative guidelines in a clear, concise, and complete way so they could enable patient-specific decision-support at the point of care during clinical encounters. This work started with the Inter-Med Project. See selected publications

In Nov. 2011 I started coordinating the ICT FP7 UE project MobiGuide: Guiding Patients Anytime Everywhere. This large-scale IP project develops a patient-centric DSS, distributed between web-based and mobile system that has wearable sensors+Smartphone

We have implemented a diabetic foot guideline in the GLIF3 language and linked it with an electronic medical record system at RAMBAM Medical Center

We developed the KDOM ontology for mapping knowledge bases to databases. This ontology allows us to reuse the same encoded guideline in multiple electronic medical record systems. See our JBI paper.

I am now focusing on design patterns for clinical guidelines and on ontologies for expressing clinical statements

Conte Center for Computational Systems Genomics of Neuropsychiatric Phenotypes - we propose to design and validate a battery of novel analytical tools for the inference of causal relationships among human genomic variations, environmental factors, and more than one mental health phenotype, explicitly exploiting the genetic and
environmental non-independence of complex (multigenic) disorders.

Access-control mechanisms that preserve patient privacy while allowing access to needed data. Our model, SitBAC, is based on characterizing Situations of access-control, rather than being simply role-based. SitBAC is formally represented in OWL. See our JBI paper

Combining clustering and ontologies to discover data-based and literature-based patient phenotypes with multiple developmental disorders. We combined self-organizing maps with a frame-based ontology. See our JBI paper.

Modeling and simulation of biological systems - I am extending the knowledge-model of biological process and function that I started developing as part of the Malaria project. Areas that I am concentrating on include dynamic simulation using mathematical models of concurrent systems (Petri-Net-based models) as well as handling contradictory information and relating phenotypic behavior to molecular-level functions. See selected publications

GLIF - a computer-interpretable language for representing the logic in clinical guidelines. This work started with the Inter-Med Project

Standardizing common components of computer-interpretable guideline models

OPM/T - A graphical object-oriented language for specifying complex dynamic systems. This work is part of the OPCAT project

last updated Oct 10, 2016